THE PLATELET PROTEOME AND CRITICAL LIMB ISCHAEMIA

Szabóová E., Koščo M.

Department of Angiology, PJ Šafárik University and East Slovak Institute of Cardiovascular Diseases, Košice

Abnormal platelet function with an increased tendency to aggregate is implicated in the pathogenesis of atherosclerosis and development of superimposed acute ischaemic events. Conflicting results have been reported regarding platelet reactivity in PAD, possibly related to different patterns of platelet reactivity in different stages of PAD, mainly in critical limb ischaemia.

The platelet proteome is the pool of platelet proteins expressed at a given time and circumstance. Over 1 100 platelet proteins have been identified using proteomic techniques. Proteomic approaches have uncovered novel signaling pathways and secreted proteins involved in platelet activation and inhibition (platelet releases – the “secretome”, alpha and dense granules, membrane and cytoskeletal proteins, platelet-derived microparticles, platelet “phosphoproteome”) which may be useful in identification of potential therapeutic targets in atherothrombosis.